16 DIGESTION AND ABSORPTION

Digestion

The process in alimentary canal by which the complex food is converted mechanically and biochemically into simple substances suitable for absorption and assimilation in the body of animals/ organisms.

Alimentary canal begin with anterior opening mouth and opens out posteriorly through anus. It comprises of following parts:

Mouth:

Mouth leads to oral cavity or buccal cavity which contains teeth and tongue.

Types of teeth

Papillae:

Upper surface of tongue has small projections called Papillae, some of which contain taste buds.

Thecodont:

Each teeth is embedded in socket of jaw bone (thecodont).

Diphyodont:

Milk teeth is replaced by permanent or adult teeth, this type of dentition is called diphyodont.

Heterodont:

Four different types of teeth (Heterodont) are incisors (I), canine (C), premolar (PM) and molar (M).

Canine: For tearing

Incisors: For cutting

Premolars: For grinding

Molars: For churning and grinding

Dental formula of man: (Permanent Teeth)

Dental formula of man: (Milk Teeth)

Pharynx:

Pharynx oral cavity opens into pharynx which acts as common passage for food and air. Cartilaginous flap called epiglottis prevents the entry of food into wind pipe (glottis) during swallowing.

Stomach:

Stomach Oesophagus leads to stomach. The opening of stomach is guarded by a sphincter (gastro-oesophageal). Stomach is divided into three parts- cardiac, fundic and pyloric.

Small intestine:

Small intestine is the longest part of alimentary canal divided into duodenum, jejunum and ileum. Pyloric sphincter is present between stomach and duodenum.

Large intestine:

Large intestine ileum opens into large intestine, which is divided into caecum, colon and rectum. Caecum is a blind sac which host microbes. Vermiform appendix arises from caecum. Rectum opens through anus.

Histology of Alimentary canal

The wall of alimentary canal from Oesophagus to rectum consists of four layers.

Serosa:

Serosa it is the outermost layer made up of squamous epithelium and areolar connective tissue.

Muscularis:

Muscularis it is composed of outer longitudinal and inner circular muscle fibres. Muscles fibers are smooth and have network of nerve cells.

Submucosa:

Submucosa it consists of loose connective tissue richly supplied with blood and lymphatic vessels. Meissner’s plexus is present between the muscular coat and mucosa that controls the secretion of intestinal juice.

Mucosa:

Mucosa is innermost layer lining the lumen of the alimentary canal. It has irregular folding in stomach called rugae and villi in small intestine. Mucosa forms glands in the stomach (gastric glands) and crypts in between the bases of villi in the intestine (crypts of Lieberkuhn).

Digestive Glands

Salivary Glands

Liver

Pancreas

Salivary Glands:

Salivary Glands secrete saliva in oral cavity. In human being’s salivary glands are three pairs- parotid, sublingual, and submandibular.

Liver:

Liver it is the largest gland in human body lies in upper right side of the abdominal cavity just below the diaphragm. Hepatic lobules, covered by Glisson’s capsule, are structural and functional unit of liver made up of hepatic cells.

The secretion is stored and concentrated in gall bladder. Bile duct and pancreatic duct open together in duodenum by common duct guarded by sphincter of Oddi.

16 DIGESTION AND ABSORPTION , LIVER

Pancreas:

Pancreas It is soft lobulated greyish pink gland which weighs about 60 gm., consists of exocrine and endocrine portion.

The exocrine portion secretes alkaline pancreatic juice and endocrine secretes hormones insulin and glucagon.

Digestion of food

Carbohydrates, fats, proteins and nucleic acids occur in food in the form of large and complex insoluble macromolecules (polymers).

These macromolecules are converted into small monomers by the action of enzyme.

In buccal cavity, teeth and tongue help in mastication and mixing of food. Mucus in saliva mix with masticated food to form bolus.

Bolus is passed to pharynx and Oesophagus by swallowing or deglutition.

Chemical digestion of food starts in oral cavity by the action of enzyme salivary amylase and lysozyme.

Lysozyme acts as antibacterial agent in mouth to prevent infection.

Salivary amylase breakdown starch into maltose

Mucosa of stomach have gastric glands having three types of cells- mucus neck cells that secrete mucus, peptic or chief cells that secretes proenzyme pepsinogen and pariental or oxyntic cells that secretes HCl.

Food mixes with gastric juice due to churning action of muscular wall to form chyme. HCl activates the pepsinogen to pepsin to digest protein into peptones and proteoses

Mucus and bicarbonates present in gastric juice play important role in lubrication and protecting inner wall of stomach from the action of HCl. Renin is a proteolytic enzyme found in gastric juice of infants to digest milk protein.

The Bile, pancreatic juice and intestinal juice are released in small intestine. Pancreatic juice contain inactive trypsinogen, chymotrypsinogen, procarboxypeptidases, amylases, lipases and nucleases.

Trypsinogen is activated by enzyme enterokinase in to trypsin, which further activates the other enzyme of intestinal juice.

Bile contains bile pigments (bilirubin and bil-verdin), bile salts, cholesterol and phospholipids which help in emulsification of fats.

Secretion of brush border cells of mucosa and goblet cells contain enzyme succus entericus, containing variety of enzymes to complete the process of digestion.

Function of large intestine

Absorption of water, minerals, and certain drugs.

Secretion of mucus for adhering of the undigested food and lubricating it for easy passage.

Absorption of Digested Food:

Absorption is the process by which nutrients pass from the alimentary canal into the blood and lymph through its mucous membrane.

Amino acids, monosaccharide, fatty acids, glycerol, salts, vitamins, and water are to be absorbed. About 90% of absorption occurs in small intestine and rest 10% in stomach, mouth and large intestine.

The passage of different absorbent depends upon concentration gradient for some substances like glucose and amino acids and electrolytes.

Absorption in different part of alimentary canal

Mouth:

Certain drugs coming in contact with the mucosa of mouth and lower side of tongue are absorbed into the blood capillaries lining them.

Stomach:

Absorption of water, simple sugar and alcohol takes place.

Small intestine:

Glucose, fructose, fatty acids, glycerol and amino acids are absorbed through the mucosa into the blood stream and lymph.

Large intestine:

Absorption of water, some minerals and drug takes place.

Disorder of Digestive System

The inflammation of intestinal tract due to bacterial infection, fungal infection and parasitic infection caused by tapeworm, round worm, threadworm and pin worms.

Jaundice:

Jaundice it is a disease of liver. In jaundice the skin and the eyes turn yellow due to large quantities of bilirubin pigments in the extra cellular fluid.

Vomiting:

Vomiting it is the ejection of stomach content through the mouth. This reflex action is controlled by the vomit Centre in the medulla.

Diarrhea:

Diarrhea frequent defection of liquid faeces is known as Diarrhea. It reduces the absorption of food.

Constipation:

Constipation in constipation the faeces are retained within the rectum as the bowel movements occur irregularly.

Indigestion:

Indigestion incomplete digestion usually accompanied by one or more of the following symptoms- pain, nausea, vomiting, heartburn, acid regurgitation, accumulation of gas and escape of gas from the stomach.

PRACTICE QUESTIONS

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